Welcome to the Hoffman Lab's website! We are lucky to be part of a vibrant research community at BC Children's Hospital, working together to understand and find a cure for diabetes.

Our research centres around the dynamic relationship between Trithorax group-mediated histone methylation and gene expression, and the ways in which this relationship drives the development and function of the endocrine pancreas. Click the link below to discover more about our specific research projects.


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E12.5 mouse pancreas
Green = Sox9
Red = Pdx1
Blue = Nuclei
Pancreatic islet from adult mouse. 
Red = GLUT2
Green = Insulin
Blue = Glucagon
White = Nuclei